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Laura Silvestri Selected Research

Iron-Refractory Iron Deficiency Anemia

8/2022The mutual crosstalk between iron and erythropoiesis.
1/2019Hepcidin and the BMP-SMAD pathway: An unexpected liaison.
1/2019Hepcidin and Anemia: A Tight Relationship.
12/2016Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.
11/2014Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.
6/2013Iron refractory iron deficiency anemia.
5/2010Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA).
5/2009Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia.

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Laura Silvestri Research Topics

Disease

15Iron Overload
01/2020 - 05/2007
13Iron Deficiencies
08/2022 - 01/2008
13Anemia
08/2022 - 08/2007
8Inflammation (Inflammations)
08/2022 - 12/2008
8Iron-Refractory Iron Deficiency Anemia
08/2022 - 05/2009
5Hemochromatosis (Bronze Diabetes)
10/2020 - 11/2010
4Hypoxia (Hypoxemia)
10/2021 - 01/2008
4Iron-Deficiency Anemia (Anemia, Iron Deficiency)
01/2021 - 10/2011
4Thalassemia
01/2020 - 11/2018
3type 2 Hemochromatosis
12/2015 - 05/2007
3Neoplasms (Cancer)
10/2003 - 07/2002
3Liver Diseases (Liver Disease)
10/2003 - 07/2002
2COVID-19
10/2021 - 01/2021
2Liver Neoplasms (Liver Cancer)
10/2003 - 04/2003
1Adenoma (Adenomas)
01/2019
1Hemorrhage
01/2019
1hypochromic microcytic Anemia
11/2014
1Polycythemia (Erythrocytosis)
06/2014
1type 3 Hemochromatosis
01/2014
1Hypochromic Anemia (Chlorosis)
06/2013
1Splenomegaly
05/2012
1beta-Thalassemia (Cooley's Anemia)
05/2012
1Chronic Disease (Chronic Diseases)
07/2011
1Sideroblastic Anemia
05/2010
1Alzheimer Disease (Alzheimer's Disease)
09/2008
1Parkinsonian Disorders (Parkinsonism)
11/2005
1Hereditary Spastic Paraplegia
11/2003
1Hepatitis C
10/2003
1Chronic Hepatitis C
10/2003
1Fibrosis (Cirrhosis)
04/2003
1Hepatitis
04/2003
1Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
08/2002

Drug/Important Bio-Agent (IBA)

28HepcidinsIBA
08/2022 - 05/2007
28IronIBA
08/2022 - 05/2007
6Transferrin (beta 2 Transferrin)IBA
01/2019 - 10/2011
6matriptase 2IBA
12/2016 - 12/2008
5Transferrin Receptors (Transferrin Receptor)IBA
08/2022 - 11/2010
4ErythropoietinFDA Link
08/2022 - 12/2014
4Proteins (Proteins, Gene)FDA Link
10/2021 - 11/2010
3Hormones (Hormone)IBA
01/2019 - 10/2003
3Serine Proteases (Serine Protease)IBA
12/2016 - 12/2008
3EnzymesIBA
10/2003 - 07/2002
2Ferritins (Ferritin)IBA
01/2021 - 10/2011
2LigandsIBA
01/2020 - 01/2016
2Hemoglobins (Hemoglobin)IBA
01/2019 - 02/2015
2Messenger RNA (mRNA)IBA
01/2015 - 07/2011
2Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
07/2011 - 10/2008
2Iron Regulatory Protein 1IBA
05/2010 - 08/2007
2GlutaredoxinsIBA
05/2010 - 08/2007
2Heme (Haem)IBA
05/2010 - 08/2007
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2021
1lactate dehydrogenase C4IBA
10/2021
1AlarminsIBA
10/2021
1AdipokinesIBA
10/2021
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2021
1CreatinineIBA
10/2021
1CytokinesIBA
10/2021
1Biomarkers (Surrogate Marker)IBA
10/2021
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2021
1metal transporting protein 1 (ferroportin)IBA
01/2020
1Interleukin-6 (Interleukin 6)IBA
01/2020
1Bone Morphogenetic Protein ReceptorsIBA
01/2020
1Glucose (Dextrose)FDA LinkGeneric
01/2019
1HematinicsIBA
11/2018
1Sirolimus (Rapamycin)FDA Link
11/2017
1Tacrolimus Binding Protein 1A (FKBP12)IBA
11/2017
1ImmunophilinsIBA
11/2017
1Dietary IronIBA
01/2016
1Bone Morphogenetic Protein 6IBA
01/2016
1Erythropoietin Receptors (Erythropoietin Receptor)IBA
04/2015
1Nonsense Codon (Nonsense Mutation)IBA
11/2014
1Glycoproteins (Glycoprotein)IBA
06/2014
1LipopolysaccharidesIBA
07/2011
1Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA
07/2011
1ElementsIBA
05/2010
1Aconitate Hydratase (Aconitase)IBA
05/2010
1Peptides (Polypeptides)IBA
12/2008
1Amyloid beta-PeptidesIBA
09/2008
1FurinIBA
01/2008
1SulfurIBA
08/2007
1Phosphotransferases (Kinase)IBA
11/2005
1m-AAA proteasesIBA
11/2003
1Metalloproteases (Metalloproteinases)IBA
11/2003
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
10/2003
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
10/2003
1AndrogensIBA
10/2003
1CytochromesIBA
10/2003
1SteroidsIBA
10/2003
1Estrogens (Estrogen)FDA Link
10/2003
1Cytochrome P-450 CYP1A2 (CYP1A2)IBA
04/2003
1Cytochrome P-450 CYP2D6 (CYP2D6)IBA
04/2003
1Cytochrome P-450 CYP2E1 (CYP2E1)IBA
04/2003
1Cytochrome P-450 CYP1A1 (CYP1A1)IBA
04/2003
1DNA Polymerase gammaIBA
08/2002
1Mitochondrial DNA (mtDNA)IBA
08/2002
1Epoxide HydrolasesIBA
07/2002

Therapy/Procedure

2Transplantation
01/2021 - 01/2019
1Therapeutics
01/2020
1Injections
06/2013
1Blood Transfusion (Blood Transfusions)
08/2007